PBworks has a page dedicated to the ways that teachers can use avatars and 3D animation in education, and a variety of 2.0 tools for this topic.
WillowStar is a completely animated, online, 3D, K-12 school. Each student is an avatar and attends school in a virtual project-based world.
Blabberize let users make pictures talk, by animating the mouth. Simple and free.
Bitstrips: Make and use comics in the classroom.
Pixton: Make comics with grammar and spell-checking available.